From Fiumicino Airport Leonardo da Vinci you can take the shuttle train Leonardo Expess till Termini Railway Station. From Termini Station the Guest House can be easily reached by taxi in 10 minutes, or by the subway (Line A) wich is only 3 stops till Spagna or bus 175 to Piazza san Silvestro, Via della Mercede is only a few steps away. An alternative public transport is the small electric shuttle bus number 116. If you are travelling by car there are two private pay parking nearby Via Ludovisi.